Zinc, insulin, and the liver: a ménage à trois.

Ménage à trois

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'.

The main ionotropic receptors (GABAA, NMDA and AMPA) display a sequential participation in neuronal excitation in the neonatal hippocampus. GABA, the principal inhibitory transmitter in the adult CNS, acts as an excitatory transmitter in early postnatal stage. Glutamatergic synaptic transmission is first purely NMDA-receptor based and lacks functional AMPA receptors. Therefore, initially glutam...

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Participation in Leisure and Sports by People with Disability Living in Rural Areas; Vision of Stakeholders in Quebec

People with disability face many constraints that affect their participation in leisure and sports, which can be seen in the gaps in the scientific literature. This study aims to document the specific issues in the leisure and sports participation of people with disability in rural areas. Qualitative research has documented the rurality-related items. Overall, stakeholders (n = 35) working with...